ncRNA name | hsa-miR-181a |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | RB cell line Y79 |
Methods | MTT assay, qRT-PCR, xenograft |
Expression pattern | associated |
Functional description | Gene analysis shows that miR-181a decreases the expression of anti-proliferative gene MAPK1 and anti-apoptotic gene Bcl-2, but significantly increased the expression of pro-apoptotic gene BAX. Melphalan and miR-181a have a complementary effect in reducing the viability of cultured Rb cells and decreasing Rb cell counts in an in-vivo xenograft Rb model in rats. |
PubMed ID | 30776396 |
Year | 2019 |
Title | Co-delivery of miR-181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma. |
Drug-related ncRNA | YES (melphalan) |
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